Cape Town International Airport (IATA: CPT) is the primary airport serving the city of Cape Town, and is the second busiest airport in South Africa and third busiest in Africa. Located approximately 20 kilometres (12 mi) from the city centre, the airport was opened in 1954 to replace Cape Town's previous airport in the suburb of Wingfield.
Cape Town International Airport is the only airport in the Cape Town metropolitan area that offers scheduled passenger services.
Here are some of the major Airlines that service Cape Town International Airport:
South African Airways
South African Express
Virgin Atlantic Airways
The above mentioned information is taken from: http://en.wikipedia.org/wiki/Cape_Town_International_Airport.